MZ3 can induce G2/M-phase arrest and apoptosis in human leukemia cells

@article{Fang2008MZ3CI,
  title={MZ3 can induce G2/M-phase arrest and apoptosis in human leukemia cells},
  author={Liang Fang and Li Shen and Yanfen Fang and Yongzhou Hu and Qiaojun He and Bo Yang},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2008},
  volume={134},
  pages={1337-1345}
}
4-(4-Bromopheny1)-2,3-dihydro-N,3-bis(3,4,5-trimethoxyphenyl)-2-oxoidmi-dazole-1-carboxamide (MZ3) is one of the novel synthesized Combretastatin A-4 analogs. In previous research, we found that MZ3 is a potent and specific compound against leukemia cell lines both in vitro and in vivo. In this paper, our purpose is to investigate the mechanisms of MZ3 induced cell cycle arrest and apoptosis in K562 cells. Cytotoxicity was measured by MTT method; apoptosis and cell cycle arrest were measured by… CONTINUE READING
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