MYH9 is associated with nondiabetic end-stage renal disease in African Americans

  title={MYH9 is associated with nondiabetic end-stage renal disease in African Americans},
  author={W. H. Kao and Michael J. Klag and L. Meoni and David M Reich and Yvette Berthier-Schaad and Man Li and Josef Coresh and Nick Patterson and Arti Tandon and Neil R. Powe and Nancy E. Fink and John H. Sadler and Matthew R. Weir and Hanna Emily Abboud and Sharon G. Adler and Jasmin Divers and Sudha K. Iyengar and Barry I. Freedman and Paul L. Kimmel and William C. Knowler and Orly F. Kohn and Kristopher Kramp and David J. Leehey and Susanne B. Nicholas and Madeleine Valdes Pahl and Jeffrey R. Schelling and John R Sedor and Denyse P. Thornley-Brown and Cheryl A. Winkler and Michael Smith and Rulan S. Parekh},
  journal={Nature Genetics},
As end-stage renal disease (ESRD) has a four times higher incidence in African Americans compared to European Americans, we hypothesized that susceptibility alleles for ESRD have a higher frequency in the West African than the European gene pool. We carried out a genome-wide admixture scan in 1,372 ESRD cases and 806 controls and found a highly significant association between excess African ancestry and nondiabetic ESRD (lod score = 5.70) but not diabetic ESRD (lod = 0.47) on chromosome 22q12… CONTINUE READING
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