MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development.

@article{Alam2009MYCNPT,
  title={MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development.},
  author={Goleeta N. Alam and Hongjuan Cui and Huilin Shi and Liqun Yang and Jane L. Ding and Ling Mao and William A Maltese and H T Ding},
  journal={The American journal of pathology},
  year={2009},
  volume={175 2},
  pages={856-66}
}
Amplification of the oncogene MYCN is a tumorigenic event in the development of a subset of neuroblastomas that commonly consist of undifferentiated or poorly differentiated neuroblasts with unfavorable clinical outcome. The cellular origin of these neuroblasts is unknown. Additionally, the cellular functions and target cells of MYCN in neuroblastoma development remain undefined. Here we examine the cell types that drive neuroblastoma development in TH-MYCN transgenic mice, an animal model of… CONTINUE READING
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