MYCN gene amplification in rhabdomyosarcoma.

  title={MYCN gene amplification in rhabdomyosarcoma.},
  author={David Kevin Driman and Paul Scott Thorner and Mark L. Greenberg and Susan Chilton-Macneill and Jeremy Squire},
  volume={73 8},
BACKGROUND Amplification of the MYCN oncogene, formerly known as N-myc, has been seen in several malignant tumors, particularly neuroblastoma, where its association with a poor clinical outcome is the clearest example of a clinically relevant oncogene mutation in any human cancer. METHODS The incidence and clinical significance of MYCN amplification in rhabdomyosarcoma (RMS) was assessed by Southern blot analysis in this retrospective study of seven alveolar RMS and six embryonal RMS… CONTINUE READING


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