MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation

@article{Delaidelli2017MYCNAN,
  title={MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation},
  author={Alberto Delaidelli and Gian Luca Negri and Asad Jan and Brandon Jansonius and Amal M El-Naggar and Jonathan K M Lim and Debjit Khan and Htoo Zarni Oo and Christopher J. Carnie and Marc Remke and John M. Maris and Gabriel Leprivier and Poul H. B. Sorensen},
  journal={Cell Death and Differentiation},
  year={2017},
  volume={24},
  pages={1564-1576}
}
MYC family proteins are implicated in many human cancers, but their therapeutic targeting has proven challenging. MYCN amplification in childhood neuroblastoma (NB) is associated with aggressive disease and high mortality. Novel and effective therapeutic strategies are therefore urgently needed for these tumors. MYC-driven oncogenic transformation impairs cell survival under nutrient deprivation (ND), a characteristic stress condition within the tumor microenvironment. We recently identified… CONTINUE READING
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MYC, metabolism, cell growth, and tumorigenesis.

Cold Spring Harbor perspectives in medicine • 2013

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