MYCN amplification confers enhanced folate dependence and methotrexate sensitivity in neuroblastoma

Abstract

MYCN amplification occurs in 20% of neuroblastomas and is strongly related to poor clinical outcome. We have identified folate-mediated one-carbon metabolism as highly upregulated in neuroblastoma tumors with MYCN amplification and have validated this finding experimentally by showing that MYCN amplified neuroblastoma cell lines have a higher requirement… (More)

1 Figure or Table

Topics

  • Presentations referencing similar topics