MYC translocation partner gene determines survival of patients with large B-cell lymphoma with MYC- or double-hit MYC/BCL2 translocations.

@article{Pedersen2014MYCTP,
  title={MYC translocation partner gene determines survival of patients with large B-cell lymphoma with MYC- or double-hit MYC/BCL2 translocations.},
  author={Mette \Olgod Pedersen and Anne Ortved Gang and Tim Svenstrup Poulsen and Helle Knudsen and Anne M Falensteen Lauritzen and Signe Lidou Nielsen and T W Klausen and Peter H N\orgaard},
  journal={European journal of haematology},
  year={2014},
  volume={92 1},
  pages={42-8}
}
In large B-cell lymphoma (LBCL) MYC- and MYC/BCL2 double-hit (DH) translocations have been associated with inferior survival. We hypothesised that the negative prognostic impact of MYC translocation was determined by an immunoglobulin MYC translocation partner gene (IG-MYC), as opposed to a non-immunoglobulin partner gene (nonIG-MYC). In a prospective, unselected cohort of 237 LBCL patients MYC and BCL2 translocations were identified by fluorescent in situ hybridisation (FISH) with split probes… CONTINUE READING
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