MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis

@inproceedings{Sochalska2017MYCSA,
  title={MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis},
  author={Maja Sochalska and Francesca Schuler and Jeffrey Weiss and Michaela Prchal-Murphy and Veronika Sexl and Andreas Villunger},
  booktitle={Oncogene},
  year={2017}
}
Rearrangements of MYC or ABL proto-oncogenes lead to deregulated expression of key-regulators of cell cycle and cell survival, thereby constituting important drivers of blood cancer. Members of the BCL-2 family of apoptosis regulators contribute to oncogenic transformation downstream of these oncogenes, but the role of anti-apoptotic BCL2A1/A1 in transformation and drug resistance caused by deregulation of these oncogenes remains enigmatic. Here we analyzed the role of A1 in MYC as well as ABL… CONTINUE READING
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