MYC is amplified in BRCA1-associated breast cancers.

  title={MYC is amplified in BRCA1-associated breast cancers.},
  author={Tatyana A. Grushko and James J. Dignam and Soma Das and Anne M Blackwood and Charles M. Perou and Karin K Ridderstr{\aa}le and Kristin N Anderson and Min-jie Wei and April Adams and Fitsum G. Hagos and Lise Sveen and Henry T. Lynch and Barbara L. Weber and Olufunmilayo I. Olopade},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={10 2},
PURPOSE Germ-line mutations in the BRCA1 tumor suppressor gene predispose to early onset breast cancers with a distinct phenotype characterized by high tumor grade, aneuploidy, high proliferation rate, and estrogen receptor-negativity. The molecular mechanisms and cooperative oncogenes contributing to multistep tumor progression in cells lacking BRCA1 are not well defined. To examine whether C-MYC (MYC), a transforming oncogene associated with genetic instability, contributes to multistep tumor… CONTINUE READING


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