MYC-dependent regulation and prognostic role of CIP2A in gastric cancer.

@article{Khanna2009MYCdependentRA,
  title={MYC-dependent regulation and prognostic role of CIP2A in gastric cancer.},
  author={Anchit Khanna and Camilla B{\"o}ckelman and Annabrita Hemmes and Melissa R Junttila and J P Wiksten and Mikael Lundin and Siina Junnila and Daniel J Murphy and Gerard I. Evan and Caj Haglund and Jukka Westermarck and Ari Ristim{\"a}ki},
  journal={Journal of the National Cancer Institute},
  year={2009},
  volume={101 11},
  pages={793-805}
}
BACKGROUND Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified human oncoprotein that stabilizes the c-Myc (MYC) protein. However, the clinical relevance of CIP2A to human cancers had not been demonstrated, but the mechanism of its regulation and its clinical role in cancer were completely unknown. METHODS Tissue microarrays consisting of 223 gastric adenocarcinoma specimens were evaluated for the presence of CIP2A using immunohistochemistry, and the association of… CONTINUE READING

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