MYC-associated and double-hit lymphomas: a review of pathobiology, prognosis, and therapeutic approaches.

@article{Petrich2014MYCassociatedAD,
  title={MYC-associated and double-hit lymphomas: a review of pathobiology, prognosis, and therapeutic approaches.},
  author={Adam M. Petrich and Chadi Nabhan and Sonali M Smith},
  journal={Cancer},
  year={2014},
  volume={120 24},
  pages={3884-95}
}
Aberrant expression of the v-myc avian myelocytomatosis viral oncogene homolog (MYC) proto-oncogene has known transformative potential in healthy human cells. Chromosomal MYC rearrangements and consequent MYC overexpression is the defining lesion in Burkitt lymphoma (BL), conferring a highly proliferative state. However, abnormalities of MYC are increasingly appreciated in non-BL histologies, including diffuse large B-cell lymphoma (DLBCL) and B-cell lymphomas intermediate between BL and DLBCL… CONTINUE READING
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Results of a phase I study of idelalisib, a PI3Kd inhibitor, in patients with relapsed or refractory mantle cell lymphoma (MCL) [published online ahead of print

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