MYC and Breast Cancer.

  title={MYC and Breast Cancer.},
  author={Jinhua Xu and Yinghua Chen and Olufunmilayo I. Olopade},
  journal={Genes & cancer},
  volume={1 6},
MYC is a key regulator of cell growth, proliferation, metabolism, differentiation, and apoptosis. MYC deregulation contributes to breast cancer development and progression and is associated with poor outcomes. Multiple mechanisms are involved in MYC deregulation in breast cancer, including gene amplification, transcriptional regulation, and mRNA and protein stabilization, which correlate with loss of tumor suppressors and activation of oncogenic pathways. The heterogeneity in breast cancer is… CONTINUE READING
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