MYC Gene Amplification is Often Acquired in Lethal Distant Breast Cancer Metastases of Unamplified Primary Tumors

Abstract

In breast cancer, amplification of MYC is consistently observed in aggressive forms of disease and correlates with poor prognosis and distant metastases. However, to date, a systematic analysis of MYC amplification in metastatic breast cancers has not been reported. Specifically, whether the MYC amplification status may change in metastases in comparison to… (More)
DOI: 10.1038/modpathol.2011.171

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@inproceedings{Singhi2012MYCGA, title={MYC Gene Amplification is Often Acquired in Lethal Distant Breast Cancer Metastases of Unamplified Primary Tumors}, author={Aatur D Singhi and Ashley M Cimino-Mathews and Robert Brian Jenkins and Fusheng Lan and S. Fink and Hind Nassar and Russell Vang and John H. Fetting and Jessica A Hicks and Saraswati V. Sukumar and Angelo M De Marzo and Pedram Argani}, booktitle={Modern Pathology}, year={2012} }