MYC Deregulation in Gastric Cancer and Its Clinicopathological Implications

  title={MYC Deregulation in Gastric Cancer and Its Clinicopathological Implications},
  author={Carolina Rosal Teixeira de Souza and Mariana Ferreira Leal and Danielle Queiroz Calcagno and Eliana Kelly Costa Sozinho and B N Borges and Raquel C Montenegro and {\^A}ndrea Kely Campos Ribeiro dos Santos and Sidney Emanuel Batista Dos Santos and Helem Ferreira Ribeiro and Paulo Pimentel de Assumpç{\~a}o and Mar{\'i}lia de Arruda Cardoso Smith and Rommel M{\'a}rio Rodr{\'i}guez Burbano},
  booktitle={PloS one},
Our study investigated the relationship between MYC alterations and clinicopathological features in gastric cancers. We evaluated the effect of MYC mRNA expression and its protein immunoreactivity, as well as copy number variation, promoter DNA methylation, and point mutations, in 125 gastric adenocarcinoma and 67 paried non-neoplastic tissues. We observed that 77% of the tumors presented MYC immunoreactivity which was significantly associated with increased mRNA expression (p<0.05). These… CONTINUE READING


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DNA hypomethylation and activation of germline-specific genes in cancer.

Advances in experimental medicine and biology • 2013
View 1 Excerpt

MYC on the Path to Cancer

Cell • 2012
View 1 Excerpt

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