MYC/BCL2 double-hit high-grade B-cell lymphoma.

  title={MYC/BCL2 double-hit high-grade B-cell lymphoma.},
  author={Shaoying Li and Pei Jen Lin and KEN. H. YOUNG and Rashmi Kanagal-Shamanna and C Cameron Yin and L Jeffrey Medeiros},
  journal={Advances in anatomic pathology},
  volume={20 5},
Double-hit lymphoma (DHL) has been defined by others as a B-cell lymphoma with MYC/8q24 rearrangement in combination with a translocation involving another gene, such as BCL2, BCL3, or BCL6. The most common form of DHL has translocations involving MYC and BCL2, also known as MYC/BCL2 DHL. In recent years, a number of case series of MYC/BCL2 DHL have been published. Most cases of MYC/BCL2 DHL morphologically resemble diffuse large B-cell lymphoma (DLBCL) or B-cell lymphoma, unclassifiable, with… CONTINUE READING
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