author={A. Melvin Ramsey and Anthony S. David and Simon Wessely and Anthony J Pelosi and E. G. Dowsett},
  journal={The Lancet},

Myalgic Encephalomyelitis (ME) or What? An Operational Definition

A discriminative definition of ME contains four mandatory elements: muscle fatigability/post-exertional muscle weakness lasting for days; operational criteria for “neurological disturbance”; fluctuation of symptoms; and a prolonged relapsing course.

Myalgic Encephalomyelitis, Chronic Fatigue Syndrome, and Systemic Exertion Intolerance Disease: Three Distinct Clinical Entities

“ME/CFS” does not exist and cannot be replaced by a new clinical entity (SEID: Systemic Exertion Intolerance Disease, as recently suggested), due to the definitions of ME and CFS.

Meta-analysis investigating post-exertional malaise between patients and controls

It is suggested that post-exertional malaise should be considered a cardinal symptom of myalgic encephalomyelitis/chronic fatigue syndrome.

Kroonilise väsimuse sündroom

Kroonilise vasimuse sundroom on raske haigusseisund, mida iseloomustavad pusiv vasimustunne, mis suveneb parast minimaalset fuusilist voi emotsionaalset pingutust; kognitiivsed haired; mittekosutav

Replacing Myalgic Encephalomyelitis and Chronic Fatigue Syndrome with Systemic Exercise Intolerance Disease Is Not the Way forward

Qualitative and diagnostic issues related to SEID are discussed and a methodological solution for the current “diagnostic impasse” is proposed.

Sleep and Quality of Life in Chronic Fatigue Syndrome

QOL scores reflect findings which show that symptoms of CFS significantly undermine many facets of these individuals’ lives and significantly impair physical and social functioning as well as participation in activities of daily living.

Editorial : Chronic fatigue syndrome and depression 3 INTERPRETING DEPRESSION IN MEDICAL ILLNESS

  • Psychology, Medicine
  • 2008
Depression will be the focus of this discussion, and many of the arguments presented are relevant to other psychological categories, such as anxiety or somatization disorder; these have also been linked with CFS but to a lesser extent than depression.

Descriptors of Fatigue in Chronic Fatigue Syndrome

The multidimensional descriptive pattern characterizing the fatigue of individuals with CFS differs dramatically from the experienced fatigue of healthy controls.

Das „Chronische Müdigkeitssyndrom“

A valid diagnosis of CFS must be based on the exclusion of defined other diseases and the awareness of dealing with a hypothetical concept, as current knowledge does not yet allow specific therapeutic recommendations.

Sleep Quality and Psychological Adjustment in Chronic Fatigue Syndrome

The data suggest that primary sleep disorders in individuals with CFS are underdiagnosed in primary care settings and that the psychological disturbances seen in CFS may well be the result of living with a chronic illness that is poorly recognized or understood.



Human enteroviral infections.

  • E. Dowsett
  • Medicine
    The Journal of hospital infection
  • 1988

Postviral fatigue syndrome: time for a new approach

The findings suggest that the fruitless dichotomy of “organic versus functional” should be replaced by a multifactorial approach in the management of this distressing disorder.

Sporadic myalgic encephalomyelitis in a rural practice.

Twenty patients presenting with chronic ill-defined illnesses in a rural practice were investigated virologically. The only positive finding was the detection of elevated Coxsackie B titres in 16 of

Myalgic encephalomyelitis--report of an epidemic.

The relationship between the group B Coxsackieviruses and a wide variety of illnesses, particularly pleurodynia and myo/pericarditis, is already well established. The detection of raised levels of