MWF rats with spontaneous albuminuria inherit a reduced efficiency of nephron induction during early nephrogenesis in comparison to SHR rats.


OBJECTIVES A congenital nephron deficit has been linked to the progression of arterial hypertension and to the development of chronic kidney disease. The Munich Wistar Frömter (MWF) inbred rat develops hypertension, progressive albuminuria, and exhibits an inherited nephron deficit of about 27% compared to spontaneously hypertensive rats (SHRs) with low… (More)
DOI: 10.1097/HJH.0b013e328356a60a