MUSCLE: a multiple sequence alignment method with reduced time and space complexity

  title={MUSCLE: a multiple sequence alignment method with reduced time and space complexity},
  author={Robert C. Edgar},
  journal={BMC Bioinformatics},
  pages={113 - 113}
In a previous paper, we introduced MUSCLE, a new program for creating multiple alignments of protein sequences, giving a brief summary of the algorithm and showing MUSCLE to achieve the highest scores reported to date on four alignment accuracy benchmarks. Here we present a more complete discussion of the algorithm, describing several previously unpublished techniques that improve biological accuracy and / or computational complexity. We introduce a new option, MUSCLE-fast, designed for high… CONTINUE READING
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