MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation.

@article{Henke2007MUC5ACAM,
  title={MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation.},
  author={Markus O. Henke and Gerrit John and Michele Germann and Hermann Lindemann and Bruce K. Rubin},
  journal={American journal of respiratory and critical care medicine},
  year={2007},
  volume={175 8},
  pages={
          816-21
        }
}
  • M. Henke, G. John, +2 authors B. Rubin
  • Published 15 April 2007
  • Medicine, Biology
  • American journal of respiratory and critical care medicine
RATIONALE Cystic fibrosis (CF) is believed to be associated with mucus hypersecretion; thus, the principal airway gel-forming mucins, MUC5AC and MUC5B, are also expected to be increased relative to non-CF secretions. However, we have shown that these mucins are decreased during stable CF disease. OBJECTIVES In this study, we determine if these mucins increase during a pulmonary exacerbation of CF. METHODS Expectorated sputum was collected from 11 adults with CF during stable disease and… 
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108 Citations
Highly Influential Citations
7
Background Citations
40
Methods Citations
3
Results Citations
3

108 Citations

Citation Type

Citation Type

Mucolytics in cystic fibrosis.
Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure.
TLDR
It is shown that the concentration of mucin in CF sputum is low when measured by immunologically based techniques, and mass spectrometric analyses of CF mucins revealed mucin cleavage at antibody recognition sites, and mucin concentrations in CF secretions were higher than those in normal secretions.
Fenretinide favorably affects mucins (MUC5AC/MUC5B) and fatty acid imbalance in a manner mimicking CFTR-induced correction.
Serine Proteases Degrade Airway Mucins in Cystic Fibrosis
TLDR
It is confirmed that mucin concentrations are significantly decreased in airway secretions of subjects with cystic fibrosis who have chronic Pseudomonas aeruginosa infection, which may contribute to chronic airway infection in the CF airway.
Airway Mucin 2 Is Decreased in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization.
TLDR
Airway MUC2 levels are decreased in patients with severe COPD colonized by potentially pathogenic micro-organisms, which may indicate one of the mechanisms underlying airway colonization in patientsWith severe COPd.
Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis
CFTR, mucins, and mucus obstruction in cystic fibrosis.
TLDR
Detailed examination of CFTR expression in organs and different cell types indicates that changes inCFTR expression do not always correlate with the severity of CF disease or mucus accumulation, and the mucus hyperproduction that typifies CF does not appear to be a direct cause of a defective CFTR but, rather, to be an downstream consequence.
Mucin Secretion in Cystic Fibrosis: A Systematic Review
TLDR
Increased expression of MUC5AC in the surface epithelium and of M UC5B in the subepithelial glands may be the result of higher secretion rate of mucin into the lumen of the respiratory tract, causing mucus plaque, infection, and inflammation.
Pseudomonas infection and mucociliary and absorptive clearance in the cystic fibrosis lung
TLDR
It is concluded that the primary experimental factor affecting MCC/ABS measurements is central deposition percentage, which is associated with P. aeruginosa infection and is consistently increased in cystic fibrosis.
Mucus, phlegm, and sputum in cystic fibrosis.
  • B. Rubin
  • Medicine, Biology
    Respiratory care
  • 2009
TLDR
The scientific basis and potential mechanism of action for many medications and devices meant to improve airway hygiene in CF by assisting with sputum expectoration are discussed and the clinical evidence of their safety and effectiveness is reviewed.
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References

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TLDR
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