MUC18 Regulates Lung Rhinovirus Infection and Inflammation

  title={MUC18 Regulates Lung Rhinovirus Infection and Inflammation},
  author={Reena L Berman and Di Jiang and Qun Wu and Connor R. Stevenson and Niccolette R. Schaefer and Hong Wei Chu},
  booktitle={PloS one},
BACKGROUND MUC18 is upregulated in the lungs of asthma and COPD patients. It has been shown to have pro-inflammatory functions in cultured human airway epithelial cells during viral infections and in mice during lung bacterial infections. However, the in vivo role of MUC18 in the context of viral infections remains poorly understood. The goal of this study is to define the in vivo function of MUC18 during respiratory rhinovirus infection. METHODS Muc18 wild-type (WT) and knockout (KO) mice… CONTINUE READING