MUC16 expression and risk of adenocarcinoma metastases to peritoneum, pleura, leptomeninges, and brain.

@article{Johnson2010MUC16EA,
  title={MUC16 expression and risk of adenocarcinoma metastases to peritoneum, pleura, leptomeninges, and brain.},
  author={Maynard Dale Johnson and Fran Vito and Haodong Xu},
  journal={Applied immunohistochemistry & molecular morphology : AIMM},
  year={2010},
  volume={18 3},
  pages={
          250-3
        }
}
Approximately 5% to 15% of central nervous system metastases by solid tumors spread to the leptomeninges. Transmembrane MUC16 is thought to facilitate anchoring of metastases to other tissues particularly those expressing mesothelin such as pleura and peritoneum. Recently, we have demonstrated that mesothelin is also expressed in the leptomeninges. Mesothelin has a high affinity for MUC16 and mesothelin expressed by some adenocarcinomas. In this study, we evaluated MUC16 and mesothelin… CONTINUE READING
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