MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage.

@article{Raina2006MUC1OB,
  title={MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage.},
  author={Deepak Raina and Rehan Ahmad and Shailendra Kumar and Jian Ren and Kiyotsugu Yoshida and Surender M. Kharbanda and Donald Kufe},
  journal={The EMBO journal},
  year={2006},
  volume={25 16},
  pages={3774-83}
}
The nonreceptor c-Abl tyrosine kinase binds to cytosolic 14-3-3 proteins and is targeted to the nucleus in the apoptotic response to DNA damage. The MUC1 oncoprotein is overexpressed by most human carcinomas and blocks the induction of apoptosis by genotoxic agents. Using human carcinoma cells with gain and loss of MUC1 function, we show that nuclear… CONTINUE READING