MUC1 oncoprotein blocks death receptor-mediated apoptosis by inhibiting recruitment of caspase-8.

@article{Agata2008MUC1OB,
  title={MUC1 oncoprotein blocks death receptor-mediated apoptosis by inhibiting recruitment of caspase-8.},
  author={Naoki Agata and Rehan Ahmad and Takeshi Kawano and Deepak Raina and Surender Kharbanda and Donald Kufe},
  journal={Cancer research},
  year={2008},
  volume={68 15},
  pages={6136-44}
}
Stimulation of the death receptor superfamily induces the activation of caspase-8 and thereby the apoptotic response. The MUC1 oncoprotein is aberrantly overexpressed by diverse human malignancies and inhibits stress-induced apoptosis. The present results show that MUC1 blocks activation of caspase-8 and apoptosis in the response of malignant cells to tumor necrosis factor alpha, tumor necrosis factor-related apoptosis-inducing ligand, and Fas ligand. The results show that MUC1 associates… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

MUC1 oncoprotein activates the InB kinase h complex and constitutive NF-nB signaling

R Ahmad, D Raina, V Trivedi
Nat Cell Biol • 2007
View 16 Excerpts
Highly Influenced

TRAIL signalling: decisions between life and death.

The international journal of biochemistry & cell biology • 2007
View 13 Excerpts
Highly Influenced

cFLIP regulation of lymphocyte activation and development

Nature Reviews Immunology • 2006
View 13 Excerpts
Highly Influenced

Augmentation of Fas ligand-induced apoptosis by MUC1 mucin.

International journal of oncology • 2005
View 13 Excerpts
Highly Influenced

MUC1 oncoprotein blocks GSK3h-mediated phosphorylation and degradation of h-catenin

L Huang, D Chen, D Liu
Cancer Res • 2005
View 8 Excerpts
Highly Influenced

The MUC1 SEA module is a self-cleaving domain.

The Journal of biological chemistry • 2005
View 8 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…