MUC1 mucin is expressed on human T-regulatory cells: function in both co-stimulation and co-inhibition.

@article{Konowalchuk2012MUC1MI,
  title={MUC1 mucin is expressed on human T-regulatory cells: function in both co-stimulation and co-inhibition.},
  author={Jeffrey D. Konowalchuk and Babita Hemlata Agrawal},
  journal={Cellular immunology},
  year={2012},
  volume={272 2},
  pages={
          193-9
        }
}
MUC1 mucin, an important protein of epithelial cells and epithelial-derived carcinomas, is also expressed on activated T cells, showing both positive and negative regulatory functions. It is currently unknown whether MUC1 is a true regulatory protein of T cells and what conditions lead to MUC1 co-stimulation versus co-inhibition. We have found that MUC1 is expressed on the majority of T-regulatory cells (CD4(+)/CD25(+)/FoxP3(+)) in humans (>90%) and that CD3/MUC1 co-stimulation leads to an… CONTINUE READING
BETA