MUC1 mucin is a negative regulator of toll-like receptor signaling.

  title={MUC1 mucin is a negative regulator of toll-like receptor signaling.},
  author={Keiko Ueno and Takeshi Koga and Kosuke Kato and Douglas T Golenbock and Sandra J Gendler and Hirofumi Kai and Kwang Chul Kim},
  journal={American journal of respiratory cell and molecular biology},
  volume={38 3},
MUC1 (MUC1 in humans and Muc1 in nonhuman species) is a transmembrane mucin-like glycoprotein expressed in epithelial cells lining various mucosal surfaces as well as hematopoietic cells. Recently, we showed that Muc1(-/-) mice exhibited greater inflammatory responses to Pseudomonas aeruginosa or its flagellin compared with their wild-type littermates, and our studies with cultured cells revealed that MUC1/Muc1 suppressed the Toll-like receptor (TLR) 5 signaling pathway, suggesting its anti… CONTINUE READING

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