MUC1 initiates a calcium signal after ligation by intercellular adhesion molecule-1.

Abstract

The MUC1 mucin is normally restricted to the apical surface of breast epithelial cells. In tumors, it is frequently overexpressed and underglycosylated. The MUC1 peptide core mediates firm adhesion of tumor cells to adjacent cells via binding to intercellular adhesion molecule-1 (ICAM-1). There is increasing evidence that MUC1 is involved in signaling, with… (More)

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Cite this paper

@article{Rahn2004MUC1IA, title={MUC1 initiates a calcium signal after ligation by intercellular adhesion molecule-1.}, author={Jennifer J. Rahn and Qiang Shen and Brian K. Mah and Judith Hugh}, journal={The Journal of biological chemistry}, year={2004}, volume={279 28}, pages={29386-90} }