MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells.

@article{Saeland2009MUC1IH,
  title={MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells.},
  author={Eir{\'i}kur Saeland and Marein A. W. P de Jong and Alexey A. Nabatov and Hakan Kalay and Teunis B H Geijtenbeek and Yvette van Kooyk},
  journal={Molecular immunology},
  year={2009},
  volume={46 11-12},
  pages={
          2309-16
        }
}
Mother-to-child transmission of human immunodeficiency virus-1 (HIV-1) occurs frequently via breast-feeding. HIV-1 targets DC-SIGN+ dendritic cells (DCs) in mucosal areas that allow efficient transmission of the virus to T cells. Here, we demonstrate that the epithelial mucin MUC1, abundant in milk, efficiently bound to DC-SIGN on DC. The O-linked glycans within the mucin domain contained Lewis X structures, that were specifically recognized by the receptor. Interestingly, MUC1 prevented DC… CONTINUE READING
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