MUC1 and the MUCs: A Family of Human Mucins with Impact in Cancer Biology

  title={MUC1 and the MUCs: A Family of Human Mucins with Impact in Cancer Biology},
  author={Stephan Ernst Baldus and Katja Engelmann and Franz-Georg Hanisch},
  journal={Critical Reviews in Clinical Laboratory Sciences},
  pages={189 - 231}
Mucins represent a family of glycoproteins characterized by repeat domains and a dense O-glycosylation. During the last two decades, the gene and peptide structures of various mucins as well as their glycosylation states were partly elucidated. Characteristic tumor-associated alterations of the expression patterns and glycosylation profiles were observed in biochemical, immunochemical, and histological studies and are discussed in the light of efforts to use the most prominent member in this… 

Analysis of mucins: role in laboratory diagnosis

  • A. Mall
  • Biology, Medicine
    Journal of Clinical Pathology
  • 2008
The emerging roles of mucins such as MUC1 and MUC4 in cancer and some other diseases are discussed, and how underglycosylated and truncated mucins are exploited as markers of disease and to monitor widespread metastasis is stressed, making them useful in patient management.

Reflections on MUC1 glycoprotein: the hidden potential of isoforms in carcinogenesis

This review aims to encompass a detailed characterization of MUC1 role in carcinogenesis, highlighting recent findings in cell differentiation and uncovering new evidences of M UC1 isoforms involvement in malignant phenotype.

Overexpression and altered glycosylation of MUC1 in malignant mesothelioma

The results suggest that specific MUC1 characteristics may be useful for mesothelioma diagnosis and should also be investigated as a potential therapeutic target.

Tn Glycosylation of the MUC6 Protein Modulates Its Immunogenicity and Promotes the Induction of Th17-biased T Cell Responses*

Results indicate that Tn glycosylation of the MUC6 protein strongly affects its B and T cell immunogenicity, and might favor immune escape of tumor cells.

MUC1 and metastatic cancer

The role of M UC1 in metastatic progression is addressed by assessing clinical studies reporting MUC1 levels at various disease stages, reviewing mouse models utilized to study the role, and discussing mechanisms of Muc1 upregulation.

Transmembrane mucins as novel therapeutic targets

Rises in the normally low levels of mucin fragments in serum have been used as markers of disease, such as tumor burden, for many years and several approaches are being examined that target mucins for immunization or nanomedicine using mucin-specific antibodies.

Characterization of cancer associated mucin type O-glycans using the exchange sialylation properties of mammalian sialyltransferase ST3Gal-II.

Overall, the exchange sialylation property of ST3Gal-II provides an efficient avenue to identify mucinous proteins for applications in glycoproteomics and cancer research.

The mucin-type glycosylating enzyme polypeptide N-acetylgalactosaminyltransferase 14 promotes the migration of ovarian cancer by modifying mucin 13.

Evidence that GALNT14 may contribute to ovarian carcinogenesis through aberrant glycosylation of MUC13, but not through the IL-8 pathway is provided, providing novel insights into understanding the function of M UC13 on neoplasm metastasis and may aid in the development of new anticancer drugs for EOC.

Regulation and function of silayltransferases in pancreatic cancer

It is shown that proinflammatory cytokines regulate the cell expression of specific sialyl transferase and fucosyltransferase genes that contribute to the biosynthesis of Lewis-type and sIALylated determinants, and thus may contribute to accelerate the tumour progression.

MUC1 from the Mucin Family as Potential Tools in Breast Cancer Immunotherapy

The potential utility of breast cancer immunotherapy of MUC1, one of the first tumor antigens shown to be a target for human tumor-specific T cells, is summarized.



MUC1 and the Immunobiology of Cancer

The potential role of the different components of the immune system in MUC1 responses are discussed within the framework of how to develop logical strategies for designing clinical studies.

Biochemistry and pathological importance of mucin-associated antigens in gastrointestinal neoplasia.

MUC1 and MUC2 expression in human gallbladder carcinoma: a clinicopathological study and relationship with prognosis.

Observations suggested that MUC1 expression plays a more important role than MUC2 expression in cancer cell growth and metastasis of human gallbladder adenocarcinomas.

Human MUC1 Mucin: A Multifaceted Glycoprotein

Human MUC1 mucin, a membrane-bound glycoprotein, is a major component of the ductal cell surface of normal glandular cells. MUC1 is overexpressed and aberrantly glycosylated in carcinoma cells. The

Mechanisms underlying aberrant glycosylation of MUC1 mucin in breast cancer cells.

The mechanism for the exposure of peptide epitopes in BT20 and T47D cells is proposed to be the loss of core-2 branching leading to shorter, sialylated O-glycan chains.

Oligosaccharides Expressed on MUC1 Produced by Pancreatic and Colon Tumor Cell Lines*

An epitope-tagged form of MUC1 was developed that allowed the detection of multiple M UC1 glycoforms and established the presence of a number of important blood group and tumor-associated carbohydrate antigens on MUC 1 expressed by two pancreatic tumor cell lines and two colon tumor cell Lines.

MUC1: the polymorphic appearance of a human mucin.

The currently known MUC species can be subdivided into two groups dependent on their structural aspects and biosynthetic routes, and MUC1 and meanwhile a series of other human mucins have revealed to exhibit large domains of tandemly repeated peptides as a structural characteristic of the “real” mucins.

Mucin-type glycoproteins.

This review is designed to critically examine relations between structure and function of the different compounds categorized as mucin glycoproteins.