MUC1 and the MUCs: A Family of Human Mucins with Impact in Cancer Biology

@article{Baldus2004MUC1AT,
  title={MUC1 and the MUCs: A Family of Human Mucins with Impact in Cancer Biology},
  author={Stephan Ernst Baldus and Katja Engelmann and Franz-Georg Hanisch},
  journal={Critical Reviews in Clinical Laboratory Sciences},
  year={2004},
  volume={41},
  pages={189 - 231}
}
Mucins represent a family of glycoproteins characterized by repeat domains and a dense O-glycosylation. During the last two decades, the gene and peptide structures of various mucins as well as their glycosylation states were partly elucidated. Characteristic tumor-associated alterations of the expression patterns and glycosylation profiles were observed in biochemical, immunochemical, and histological studies and are discussed in the light of efforts to use the most prominent member in this… 
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Analysis of mucins: role in laboratory diagnosis

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  • 2008
TLDR
The emerging roles of mucins such as MUC1 and MUC4 in cancer and some other diseases are discussed, and how underglycosylated and truncated mucins are exploited as markers of disease and to monitor widespread metastasis is stressed, making them useful in patient management.

Reflections on MUC1 glycoprotein: the hidden potential of isoforms in carcinogenesis

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This review aims to encompass a detailed characterization of MUC1 role in carcinogenesis, highlighting recent findings in cell differentiation and uncovering new evidences of M UC1 isoforms involvement in malignant phenotype.

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TLDR
The results suggest that specific MUC1 characteristics may be useful for mesothelioma diagnosis and should also be investigated as a potential therapeutic target.

Tn Glycosylation of the MUC6 Protein Modulates Its Immunogenicity and Promotes the Induction of Th17-biased T Cell Responses*

TLDR
Results indicate that Tn glycosylation of the MUC6 protein strongly affects its B and T cell immunogenicity, and might favor immune escape of tumor cells.

MUC1 and metastatic cancer

TLDR
The role of M UC1 in metastatic progression is addressed by assessing clinical studies reporting MUC1 levels at various disease stages, reviewing mouse models utilized to study the role, and discussing mechanisms of Muc1 upregulation.

Transmembrane mucins as novel therapeutic targets

TLDR
Rises in the normally low levels of mucin fragments in serum have been used as markers of disease, such as tumor burden, for many years and several approaches are being examined that target mucins for immunization or nanomedicine using mucin-specific antibodies.

Characterization of cancer associated mucin type O-glycans using the exchange sialylation properties of mammalian sialyltransferase ST3Gal-II.

TLDR
Overall, the exchange sialylation property of ST3Gal-II provides an efficient avenue to identify mucinous proteins for applications in glycoproteomics and cancer research.

The mucin-type glycosylating enzyme polypeptide N-acetylgalactosaminyltransferase 14 promotes the migration of ovarian cancer by modifying mucin 13.

TLDR
Evidence that GALNT14 may contribute to ovarian carcinogenesis through aberrant glycosylation of MUC13, but not through the IL-8 pathway is provided, providing novel insights into understanding the function of M UC13 on neoplasm metastasis and may aid in the development of new anticancer drugs for EOC.

Regulation and function of silayltransferases in pancreatic cancer

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It is shown that proinflammatory cytokines regulate the cell expression of specific sialyl transferase and fucosyltransferase genes that contribute to the biosynthesis of Lewis-type and sIALylated determinants, and thus may contribute to accelerate the tumour progression.

MUC1 from the Mucin Family as Potential Tools in Breast Cancer Immunotherapy

TLDR
The potential utility of breast cancer immunotherapy of MUC1, one of the first tumor antigens shown to be a target for human tumor-specific T cells, is summarized.
...

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