MUC1 and the MUCs: A Family of Human Mucins with Impact in Cancer Biology

  title={MUC1 and the MUCs: A Family of Human Mucins with Impact in Cancer Biology},
  author={S. Baldus and K. Engelmann and F. Hanisch},
  journal={Critical Reviews in Clinical Laboratory Sciences},
  pages={189 - 231}
  • S. Baldus, K. Engelmann, F. Hanisch
  • Published 2004
  • Biology, Medicine
  • Critical Reviews in Clinical Laboratory Sciences
  • Mucins represent a family of glycoproteins characterized by repeat domains and a dense O-glycosylation. During the last two decades, the gene and peptide structures of various mucins as well as their glycosylation states were partly elucidated. Characteristic tumor-associated alterations of the expression patterns and glycosylation profiles were observed in biochemical, immunochemical, and histological studies and are discussed in the light of efforts to use the most prominent member in this… CONTINUE READING
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