MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion.

  title={MUC1 alters beta-catenin-dependent tumor formation and promotes cellular invasion.},
  author={Joyce A. Schroeder and Melissa C. Adriance and Melissa C Thompson and Todd D. Camenisch and Sandra J Gendler},
  volume={22 9},
MUC1 is aberrantly expressed in greater than 90% of all breast carcinomas, yet its function as a tumor antigen is not fully understood. Recently, studies have shown that MUC1 interacts with beta-catenin, erbB receptors, src, GSK-3beta and protein kinase Cdelta, possibly in a complex that promotes the disassembly of adherens junctions and the invasion of cells. Here we show that the deletion of Muc1 expression from MMTV-Wnt-1 transgenic mice results in a significant increase in the time to… CONTINUE READING


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