MUC1 Regulates PDGFA Expression During Pancreatic Cancer Progression

  title={MUC1 Regulates PDGFA Expression During Pancreatic Cancer Progression},
  author={Mahnaz Sahraei and Lopamudra Das Roy and J. M. Curry and Tinder L Teresa and Sritama Nath and Dahlia Marie Besmer and Amritha Kidiyoor and Ritu Dalia and Sandra J Gendler and Pinku Mukherjee},
Pancreatic ductal adenocarcinoma (PDA) has one of the worst prognoses of all cancers. Mucin 1 (MUC1), a transmembrane mucin glycoprotein, is a key modulator of several signaling pathways that affect oncogenesis, motility and metastasis. Its expression is known to be associated with poor prognosis in patients. However, the precise mechanism remains elusive. We report a novel association of MUC1 with platelet-derived growth factor-A (PDGFA). PDGFA is one of the many drivers of tumor growth… CONTINUE READING


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