MUC-1 epithelial tumor mucin-based immunity and cancer vaccines.

@article{Finn1995MUC1ET,
  title={MUC-1 epithelial tumor mucin-based immunity and cancer vaccines.},
  author={Olivera Olja J Finn and Keith R. Jerome and Robert A. Henderson and Gabriele Pecher and Nieves Dom{\'e}nech and Julie Magarian-Blander and Simon M Barratt-Boyes},
  journal={Immunological reviews},
  year={1995},
  volume={145},
  pages={
          61-89
        }
}
Many obstacles still stand in the way to eliciting an effective immune response against cancer, even though several antigens and antigenic peptides have been identified as potential tumor targets. All of them, including the MUC-1 mucin, share the caveat of being normal cellular proteins. Unlike all the others, however, MUC-1 expressed on tumors can still be considered a truly tumor-specific antigen. Its expression on normal cells is hidden from the immune system, and its aberrant glycosylation… CONTINUE READING
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