MU and delta opioid receptors control differently the horizontal and vertical components of locomotor activity in mice.

@article{MichaelTitus1989MUAD,
  title={MU and delta opioid receptors control differently the horizontal and vertical components of locomotor activity in mice.},
  author={Adina Michael-Titus and Nathalie Dourmap and Jean Costentin},
  journal={Neuropeptides},
  year={1989},
  volume={13 4},
  pages={235-42}
}
The present study investigated the role of mu and delta opioid receptors in the control of the horizontal and vertical components of locomotion. Mice received intracerebroventricularly (i.c.v.) enkephalin analogs specific for either the mu or delta opioid receptors. The administration of the specific mu agonist [D-Ala2-NMePhe4-Gly5(ol)] enkephalin (DAGO) induced a dose-dependent increase in horizontal activity and a decrease in vertical activity. The specific delta agonist [D-Pen2,D-Pen5… CONTINUE READING
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