MTX-induced white matter changes are associated with polymorphisms of methionine metabolism

@article{Linnebank2005MTXinducedWM,
  title={MTX-induced white matter changes are associated with polymorphisms of methionine metabolism},
  author={M. Linnebank and H. Pels and N. Kleczar and S. Farmand and K. Fliessbach and H. Urbach and K. Orlopp and T. Klockgether and I. Schmidt-Wolf and U. Schlegel},
  journal={Neurology},
  year={2005},
  volume={64},
  pages={912 - 913}
}
Methotrexate (MTX) is a folate antagonist inhibiting nucleic acid and methionine synthesis. Methionine is necessary for CNS myelination. In 42 patients with primary CNS lymphoma (PCNSL) treated with a systemic and intraventricular high-dose MTX-based polychemotherapy, the presence of a risk haplotype defined by polymorphisms influencing methionine metabolism referred a relative risk for CNS white matter changes of 4.7 (p = 0.001). The authors conclude that methionine metabolism influences MTX… Expand
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