MTX does not affect enhanced biosynthesis and metabolism of S-adenosylmethionine in testosterone-induced hypertrophic mouse kidney.

@article{Chmurzyska1993MTXDN,
  title={MTX does not affect enhanced biosynthesis and metabolism of S-adenosylmethionine in testosterone-induced hypertrophic mouse kidney.},
  author={W. Chmurzyńska and M. Manteuffel-Cymborowska and M. Szlazak and B. Grzelakowska-Sztabert},
  journal={Advances in experimental medicine and biology},
  year={1993},
  volume={338},
  pages={
          699-702
        }
}
In the testosterone-induced hypertrophic female mouse kidney model we recently found that one of the anabolic effects of testosterone, apart from its profound induction of ornithine decarboxylase, which results in the stimulation of putrescine biosynthesis, is the enhancement of synthesis and levels of S-adenosylmethionine (AdoMet), and an increase in cellular methylation intensity1. Synthesis of renal AdoMet may be considered to be a folate-dependent process, because of the involvement of 5… Expand
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