MTRR silencing inhibits growth and cisplatin resistance of ovarian carcinoma via inducing apoptosis and reducing autophagy.

@article{Chen2015MTRRSI,
  title={MTRR silencing inhibits growth and cisplatin resistance of ovarian carcinoma via inducing apoptosis and reducing autophagy.},
  author={Jia Jie Chen and Qi Wang and Fu-Qiang Yin and Wei Zhang and L Yan and Li Li},
  journal={American journal of translational research},
  year={2015},
  volume={7 9},
  pages={1510-27}
}
Methionine synthase reductase (MTRR) is involved in the DNA synthesis and production of S-adenosylmethionine (SAM) and plays an important role in the carcinogenesis. However, the role of MTRR in the resistance of ovarian cancer (OC) to chemotherapy has yet to be elucidated. In order to investigate the clinical significance of MTRR in OC, MTRR expression was reduced by using the RNA interference technique, and therefore, and the tumor growth and cisplatin-resistance were evaluated in vitro and… CONTINUE READING
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