MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.

  title={MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.},
  author={Denghong Zhang and Riccardo Contu and Michael V. G. Latronico and Jianlin Zhang and Roberto Rizzi and Daniele Catalucci and Shigeki Miyamoto and Katherine Huang and Marcello Ceci and Yusu Gu and Nancy D. Dalton and K Linnea Peterson and Kun Liang Guan and Joan Brown and Ju Chen and Nahum Sonenberg and Gianluigi Condorelli},
  journal={The Journal of clinical investigation},
  volume={120 8},
Mechanistic target of rapamycin (MTOR) plays a critical role in the regulation of cell growth and in the response to energy state changes. Drugs inhibiting MTOR are increasingly used in antineoplastic therapies. Myocardial MTOR activity changes during hypertrophy and heart failure (HF). However, whether MTOR exerts a positive or a negative effect on myocardial function remains to be fully elucidated. Here, we show that ablation of Mtor in the adult mouse myocardium results in a fatal, dilated… CONTINUE READING


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