MTL–Independent Phenotypic Switching in Candida tropicalis and a Dual Role for Wor1 in Regulating Switching and Filamentation

@inproceedings{Porman2013MTLIndependentPS,
  title={MTL–Independent Phenotypic Switching in Candida tropicalis and a Dual Role for Wor1 in Regulating Switching and Filamentation},
  author={Allison M. Porman and Matthew P. Hirakawa and Stephen K Jones and Na Li Wang and Richard J. Bennett},
  booktitle={PLoS genetics},
  year={2013}
}
Phenotypic switching allows for rapid transitions between alternative cell states and is important in pathogenic fungi for colonization and infection of different host niches. In Candida albicans, the white-opaque phenotypic switch plays a central role in regulating the program of sexual mating as well as interactions with the mammalian host. White-opaque switching is controlled by genes encoded at the MTL (mating-type-like) locus that ensures that only a or α cells can switch from the white… CONTINUE READING
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