MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic.

@article{Pardini2011MTHFRAM,
  title={MTHFR and MTRR genotype and haplotype analysis and colorectal cancer susceptibility in a case-control study from the Czech Republic.},
  author={Barbara Pardini and Rajiv Kumar and Alessio Naccarati and Rashmi B Prasad and Asta Forsti and Veronika Pol{\'a}kov{\'a} and Ludmila Vodi{\vc}kov{\'a} and Jan Novotn{\'y} and Kari Hemminki and Pavel Erik Vodicka},
  journal={Mutation research},
  year={2011},
  volume={721 1},
  pages={74-80}
}
Polymorphic variants in genes involved in one-carbon metabolism, in particular of dietary folate, may modulate the risk for colorectal cancer through aberrant DNA-methylation and altered nucleotide synthesis and repair. In the present study, we have assessed the association of six polymorphisms and relative haplotypes in the MTHFR gene (rs1801133 and… CONTINUE READING

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