MTHFR A1298C and C677T gene polymorphisms and susceptibility to chronic myeloid leukemia in Egypt.

@article{Aly2014MTHFRAA,
  title={MTHFR A1298C and C677T gene polymorphisms and susceptibility to chronic myeloid leukemia in Egypt.},
  author={Rabab M. Aly and Mona M. Taalab and Hayam Fathy Abd-El Hay Ghazy},
  journal={International journal of clinical and experimental pathology},
  year={2014},
  volume={7 5},
  pages={2571-8}
}
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating the intracellular folate metabolism which plays an important role in carcinogenesis through DNA methylation. We aimed to evaluate the association between MTHFR A1298C and C677T polymorphisms and the risks of chronic myeloid leukemia (CML). Eighty-five patients with CML and a control group containing 100 healthy, age and sex matched individuals were examined for MTHFR C677T and A1298C polymorphisms using polymerase chain… CONTINUE READING

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References

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Showing 1-10 of 36 references

Methylenetetrahydrofolate Reductase gene polymorphisms and risk of Myeloid Leukemia

  • P Vahid, R Farnaz, F Zaker, A Farzaneh, R Parisa
  • Lab Med
  • 2010

Methylenetet - rahydrofolate Reductase ( MTHFR ) Genotype Association with the Risk of Chronic Myelogenous Leukemia

  • SI Ismail, NA Ababneh, A Awidi
  • J Med J
  • 2009

Methy - lenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil

  • CG Barbosa, CL Souza, +4 authors MS Goncalves
  • Genet and Mol Biol
  • 2008

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