MTH1 Substrate Recognition--An Example of Specific Promiscuity.

@article{Nissink2016MTH1SR,
  title={MTH1 Substrate Recognition--An Example of Specific Promiscuity.},
  author={J. Willem M. Nissink and Michal Bista and Jason Breed and Nikki Carter and Kevin J. Embrey and Jonathan Read and Jon J Winter-Holt},
  journal={PloS one},
  year={2016},
  volume={11 3},
  pages={
          e0151154
        }
}
  • J. Willem M. Nissink, Michal Bista, +4 authors Jon J Winter-Holt
  • Published in PloS one 2016
  • Chemistry, Medicine
  • MTH1 (NUDT1) is an oncologic target involved in the prevention of DNA damage. We investigate the way MTH1 recognises its substrates and present substrate-bound structures of MTH1 for 8-oxo-dGTP and 8-oxo-rATP as examples of novel strong and weak binding substrate motifs. Investigation of a small set of purine-like fragments using 2D NMR resulted in identification of a fragment with weak potency. The protein-ligand X-Ray structure of this fragment provides insight into the role of water… CONTINUE READING

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