MTERF4 regulates the mitochondrial dysfunction induced by MPP(+) in SH-SY5Y cells.

@article{Ye2015MTERF4RT,
  title={MTERF4 regulates the mitochondrial dysfunction induced by MPP(+) in SH-SY5Y cells.},
  author={Xiaofei Ye and Yanyan Han and Linbing Zhang and Wen Liu and Ji Zuo},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={464 1},
  pages={214-20}
}
Mitochondrial transcription termination factor 4, MTERF4, a member of the MTERF family, has been implicated in the regulation of mitochondrial translation by targeting NSUN4 to the large mitochondrial ribosome. Here, we found a novel role for MTERF4 in regulating mitochondrial dysfunction induced by MPP(+). We observed that knockdown of MTERF4 in SH-SY5Y cells resulted in increased mitochondrial DNA transcription levels and decreased mitochondrial DNA translation levels. In addition, after… CONTINUE READING
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