MTC 28 , a Novel 28-Kilodalton Proline-Rich Secreted Antigen Specific for the Mycobacterium tuberculosis Complex

@inproceedings{Manca1997MTC2,
  title={MTC 28 , a Novel 28-Kilodalton Proline-Rich Secreted Antigen Specific for the Mycobacterium tuberculosis Complex},
  author={Claudia Manca and Konstantin P. Lyashchenko and Roberto Colangeli and Maria Laura Gennaro},
  year={1997}
}
Proteins that are actively secreted by Mycobacterium tuberculosis serve as major targets of immune responses in the infected host. To identify and purify novel proteins in the filtrates of M. tuberculosis cultures, a bacteriophage l library of M. tuberculosis H37Rv DNA was immunoscreened by using an anti-culture filtrate rabbit antiserum. Of 20 positive clones isolated, 6 were analyzed and found to express the genes for two known components of the early culture filtrate, the secreted 45/47-kDa… CONTINUE READING

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