MTA family of proteins in prostate cancer: biology, significance, and therapeutic opportunities

  title={MTA family of proteins in prostate cancer: biology, significance, and therapeutic opportunities},
  author={Anait S Levenson and Avinash B. Kumar and Xu Zhang},
  journal={Cancer and Metastasis Reviews},
This review summarizes our current understanding of the role of MTA family members, particularly MTA1, with a special emphasis on prostate cancer. The interest for the role of MTA1 in prostate cancer was boosted from our initial findings of MTA1 as a component of “vicious cycle” and a member of bone metastatic signature. Analysis of human prostate tissues, xenograft and transgenic mouse models of prostate cancer, and prostate cancer cell lines has provided support for the role of MTA1 in… CONTINUE READING
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