Selection Criteria The literature search included MEDLINE (via PubMed), Science-Direct, Web of Science, Cochrane, and Clinical Key databases up to December 2012. Original prospective clinical trials comparing two or more pulpotomy agents were identified. The three authors did the search and started screening titles and abstracts for potential relevant articles, then performed a quality assessment of the included articles. Any disagreements were resolved by discussion among them. A total of 2083 potential relevant titles, abstracts, and articles were identified in addition to reference lists of reviews and related articles, with 171 articles screened for further evaluation. Finally, 37 trials met all the inclusion criteria, and 22 were considered for network and pair-wise meta-analyses. Of all 37 studies, 22 were parallel trials and the others were split-mouth trials. Follow-up periods were diverse, ranging from 5.2 to between 48 and 60 months. Twenty-two studies were chosen for meta-analyses for 912 months, and 12 were chosen for metaanalyses for 1824 months. The majority of the studies were randomized controlled trials (RCTs).