MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease?


We have recently identified in a transgenic mouse model of Alzheimer’s disease (AD) membrane-type 5-MMP (MT5-MMP) as a new player in Alzheimer’s pathogenesis, which displays pro-amyloidogenic features and proteolytic processing of amyloid precursor protein (APP). Another group has reported that MT5-MMP processing of APP may release a novel neurotoxic APP fragment. Although MT5-MMP-mediated APP processing appears to be a key pathogenic step, we hypothesize that MT5-MMP may also contribute to AD pathogenesis through complementary mechanisms that involve the activation of pro-inflammatory pathways and/or APP trafficking.

DOI: 10.1186/s12974-016-0633-4

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@inproceedings{Baranger2016MT5MMPJA, title={MT5-MMP, just a new APP processing proteinase in Alzheimer’s disease?}, author={K{\'e}vin Baranger and Michel Khrestchatisky and Santiago Rivera}, booktitle={Journal of Neuroinflammation}, year={2016} }