MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin.

@article{Shi2011MT1MMPRT,
  title={MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin.},
  author={Feng Shi and Jane Sottile},
  journal={Journal of cell science},
  year={2011},
  volume={124 Pt 23},
  pages={4039-50}
}
The extracellular matrix (ECM) is dynamically remodeled by cells during development, normal tissue homeostasis and in a variety of disease processes. We previously showed that fibronectin is an important regulator of ECM remodeling. The deposition and/or polymerization of fibronectin into the ECM controls the deposition and stability of other ECM molecules. In addition, agents that inhibit fibronectin polymerization promote the turnover of fibronectin fibrils and enhance ECM fibronectin… CONTINUE READING