MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src.

@article{Eisenach2010MT1MMPRV,
  title={MT1-MMP regulates VEGF-A expression through a complex with VEGFR-2 and Src.},
  author={Patricia Alice Eisenach and Christian H. Roghi and Marton Fogarasi and Gillian Murphy and William R English},
  journal={Journal of cell science},
  year={2010},
  volume={123 Pt 23},
  pages={4182-93}
}
Membrane-type-1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I transmembrane metalloproteinase involved in pericellular proteolysis, migration and invasion, with elevated levels correlating with a poor prognosis in cancer. MT1-MMP-mediated transcriptional regulation of genes in cancer cells can contribute to tumour growth, although this is poorly understood at a mechanistic level. In this study, we investigated the mechanism by which MT1-MMP regulates the expression of VEGF-A in… CONTINUE READING

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