MT1-MMP on the cell surface causes focal degradation of gelatin films.


The membrane-type matrix metalloproteinases (MT-MMPs) are a subclass of the matrix metalloproteinase (MMP) family which uniquely possess a C-terminal transmembrane domain and are initiators of an activation cascade for progelatinase A (MMP-2). Recent studies have shown that they can also efficiently directly degrade a number of matrix macromolecules. We now show that cells expressing MT1-MMP on their cell surfaces cause subjacent proteolysis of a gelatin film and that this proteolysis is inhibited by TIMP-2 but not by TIMP-1. These data indicate that expression of MT1-MMP on the cell surface may lead to both progelatinase A activation and extracellular matrix degradation.


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@article{Dortho1998MT1MMPOT, title={MT1-MMP on the cell surface causes focal degradation of gelatin films.}, author={M P D'ortho and Harley Stanton and Michael J. Butler and Susan Atkinson and Gillian Murphy and Rosalind M. Hembry}, journal={FEBS letters}, year={1998}, volume={421 2}, pages={159-64} }