MT1-MMP modulates melanoma cell dissemination and metastasis through activation of MMP2 and RAC1.

@article{Shaverdashvili2014MT1MMPMM,
  title={MT1-MMP modulates melanoma cell dissemination and metastasis through activation of MMP2 and RAC1.},
  author={Khvaramze Shaverdashvili and Poki Wong and Jun Ma and Keman Zhang and Iman Osman and Barbara Bedogni},
  journal={Pigment cell & melanoma research},
  year={2014},
  volume={27 2},
  pages={
          287-96
        }
}
  • Khvaramze Shaverdashvili, Poki Wong, +3 authors Barbara Bedogni
  • Published 2014
  • Medicine, Biology
  • Pigment cell & melanoma research
  • Metastatic melanoma remains the deadliest of all skin cancers with a survival rate at five years of less than 15%. MT1-MMP is a membrane-associated matrix metalloproteinase that controls pericellular proteolysis and is an important, invasion-promoting, pro-tumorigenic MMP in cancer. We show that deregulation of MT1-MMP expression happens as early as the transition from nevus to primary melanoma and continues to increase during melanoma progression. Furthermore, MT1-MMP expression is associated… CONTINUE READING

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