MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development.

Abstract

Notch signalling controls the differentiation of haematopoietic progenitor cells (HPCs). Here, we show that loss of membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP14), a cell surface protease expressed in bone marrow stromal cells (BMSCs), increases Notch signalling in HPCs and specifically impairs B-lymphocyte development. When co-cultured with… (More)
DOI: 10.1038/emboj.2011.136

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Cite this paper

@article{Jin2011MT1MMPCD, title={MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development.}, author={Guoxiang Jin and Feng-ju Zhang and Kui Ming Chan and Hoi Leong Xavier Wong and Baohua Liu and Kathryn S. E. Cheah and Xin Liu and Cornelia Mauch and D. Liu and Zhongjun Zhou}, journal={The EMBO journal}, year={2011}, volume={30 11}, pages={2281-93} }